I haven't tried it myself.
But reading the manual however, shows that commands using H as the prefix use the Microchip's hardware. eg HPWM uses a set pin. You have no control over this. The standard PWM can be used on any output pin.
A major implication of this is in HSERIN/HSEROUT. Using hardware, higher data rates are now possible, but using standard SERIN/SEROUT you are limited, as the pins used are effectively a pseudo Comms port, not actual.
Hope this makes sense.